EVALUATION OF IPIL-IPIL (Leucaena leucocephala) SEED GUM AS CO-ENCAPSULATING AGENT FOR TARGETED AND CONTROLLED DELIVERY OF POWDERED INSULIN PLANT (Chamaecostus cuspidatus)

Type 2 Diabetes Mellitus (T2DM) is the most common non-communicable disease in Philippines, characterized by increased blood glucose levels brought low insulin production or resistance. Chamaecostus cuspidatus a medicinal plant known for its glucose-lowering property. The controlled release of C. leaves must be achieved to maximize antidiabetic Leucaena leucocephala an endemic tree having seed as source possible co-encapsulating material drug delivery. Galactomannan, main component isolated gum, can used substitute effective moderate intended site. Thus, this study evaluates property and stability gum agent targeted delivery leaves. encapsulation process was done through extrusion method. evaluated vitro gastrointestinal simulation analysis examined using differential scanning calorimetry (DSC), Fourier transform infrared spectrometer (FTIR), field emission electron microscope (FE-SEM) verify surface morphology. capsules were observed fully disintegrate at fed state (pH 5.4) simulated conditions, which target fingerprint on FTIR spectra encapsulated presented indicates successful incorporation powdered inside encapsulating material. Morphological micrographs have shown that resulting fairly spherical, size approximately 3.8 mm. Ridges pores are also present their immediate disintegration hydration. Therefore, L. potential candidate suitable effective, targeted, maximum benefits.